Dr Audrey Bernut | Marie Curie Post-doctoral Fellow

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Audrey is a Marie Curie Intraeuropean Postdoctoral Fellow. She is a microbiologist with a strong and long-standing interest in pulmonary infections, especially tuberculosis and cystic fibrosis (CF) pathogens. She has developed the zebrafish embryo as a new infection model of Mycobacterium abscessus and used this to assess fundamental issues like the immuno-pathogenesis of atypical mycobacterial diseases and the basis of host resistance/susceptibility or bacterial resistance/virulence.
She is interested in the role of the vicious circle of inflammation and infection which contributes to adverse outcomes in CF. Her research uses the zebrafish larvae model to explore the immune consequences of CFTR mutation and to identify potential therapeutic interventions.

Dr Noémie Hamilton | ELA Post-doctoral Fellow

Noémie isphoto-on-09-08-2016-at-14-28-1 an ELA International funded postdoctoral fellow. She has a
background in molecular biology and is an expert in modelling human diseases
using zebrafish. She is interested in how the immune response plays a role in
health and disease, especially autoimmune diseases. She has created a zebrafish
model for a human neurological disorder with mutation in the RNASET2 gene.
This zebrafish mutant has revealed critical mechanism in the pathogenesis and
she is using it as a new platform for long-term drug discovery.

Samir Morsli | PhD Student

Screen Shot 2015-12-07 at 16.26.49Samir is a 2nd year PhD student working on developing a dual-function zebrafish model to study senescence, which is a cellular response to stress that is linked to ageing and age related disorders. He is taking advantage of the way zebrafish embryos are transparent and genetically engineering cells so that they express green fluorescent protein when they become senescent. This will hopefully allow us to monitor and identify these cells in vivo, and understand more about the phenotype.


Kyle Buchan | PhD Student

Kyle is a PhD skyletudent working in our group as part of the Florey Institute for Host-Pathogen Interactions, a university initiative focusing on the relationships of important pathogens with their hosts within the context of infection. His interests concern the bacteria Staphylococcus aureus, better known in the healthcare setting as MRSA, and how it has become adapted to causing infection within humans. He aims to use a humanised zebrafish model to investigate the impact of humanisation on staphylococcal infection at the whole organism level, as well as at the cellular level in terms of how the bacteria is controlled by the innate immune system.

 


Katy Henry | Post-doctoral Researcher

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Katherine is interested in modelling disease using the zebrafish. She is particularly interested in the way in which we can influence neutrophil fate both pharmacologically and genetically using the zebrafish as a model. She is currently working on the role of kinases and the therapeutic potential of kinase inhibitors to drive neutrophilic inflammation resolution.


Catherine Loynes | Research Assistant

20180115_114511Catherine’s main interest in the lab is the interaction between key leukocytes, namely macrophages and neutrophils, during an inflammatory response. She enjoys making transgenic zebrafish to enable easy visualisation of cell interations and gene expression. Green and red labelled cells allow her to investigate processes such as apoptosis (programmed cell death), neutrophil and macrophage interaction and their function.


Matt Foulkes | PhD Student

MFoulkesMatt is an interdisciplinary final year PhD student working on a medicinal chemistry project in both our group and that of Dr. Simon Jones in the Department of Chemistry.  Specifically, Matt is interested in synthesising novel natural product-derived compounds and evaluating their effects in a transgenic zebrafish model of inflammation, with particular emphasis on the effects these molecules have on neutrophil behaviour.