Dr Audrey Bernut | Marie Curie Post-doctoral Fellow

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Audrey is a Marie Curie Intraeuropean Postdoctoral Fellow. She is a microbiologist with a strong and long-standing interest in pulmonary infections, especially tuberculosis and cystic fibrosis (CF) pathogens. She has developed the zebrafish embryo as a new infection model of Mycobacterium abscessus and used this to assess fundamental issues like the immuno-pathogenesis of atypical mycobacterial diseases and the basis of host resistance/susceptibility or bacterial resistance/virulence.
She is interested in the role of the vicious circle of inflammation and infection which contributes to adverse outcomes in CF. Her research uses the zebrafish larvae model to explore the immune consequences of CFTR mutation and to identify potential therapeutic interventions.

Dr Noémie Hamilton | ELA Post-doctoral Fellow

Noémie isphoto-on-09-08-2016-at-14-28-1 an ELA International funded postdoctoral fellow. She has a
background in molecular biology and is an expert in modelling human diseases
using zebrafish. She is interested in how the immune response plays a role in
health and disease, especially autoimmune diseases. She has created a zebrafish
model for a human neurological disorder with mutation in the RNASET2 gene.
This zebrafish mutant has revealed critical mechanism in the pathogenesis and
she is using it as a new platform for long-term drug discovery.

Samir Morsli | PhD Student

Screen Shot 2015-12-07 at 16.26.49Samir is a 3rd year PhD student working on developing a dual-function zebrafish model to study senescence, which is a cellular response to stress that is linked to ageing and age related disorders. He is taking advantage of the way zebrafish embryos are transparent and genetically engineering cells so that they express green fluorescent protein when they become senescent. This will hopefully allow us to monitor and identify these cells in vivo, and understand more about the phenotype.

 

Clare Muir | PhD Student

Clare is a veterinary pathologist who is interested in understanding how bacteria survive within immune cells. Bacteria are ‘eaten’ by a type of immune cell called a neutrophil and then become entrapped within a cytoplasmic lipid vesicle called the phagosome. This phagosome undergoes progressive changes to mediate bacterial killing. Some bacteria interfere with this normal maturation process and are therefore able to persist within the very cells which are meant to be destroying them. To do this, some bacteria manipulate the production or destruction of phosphatidylinositol lipids. These lipids are dynamically regulated at the phagosome membrane by lots of different enzymes and manipulation of these enzymes may offer a potential method of enhancing pathogen destruction whilst minimising host cell damage


Katy Henry | Post-doctoral Researcher

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Katherine is interested in modelling disease using the zebrafish. She is particularly interested in the way in which we can influence neutrophil fate both pharmacologically and genetically using the zebrafish as a model. She is currently working on the role of kinases and the therapeutic potential of kinase inhibitors to drive neutrophilic inflammation resolution.


Catherine Loynes | Research Assistant

20180115_114511Catherine’s main interest in the lab is the interaction between key leukocytes, namely macrophages and neutrophils, during an inflammatory response. She enjoys making transgenic zebrafish to enable easy visualisation of cell interations and gene expression. Green and red labelled cells allow her to investigate processes such as apoptosis (programmed cell death), neutrophil and macrophage interaction and their function.