The principle interest of the Renshaw lab is understanding how inflammation resolves or heals.
If we can understand this, we are a step closer to understanding how that fails in inflammatory diseases and to developing new treatments to treat failed inflammation resolution.
At present, work on inflammation breaks down into 5 main areas:
- Interleukin-1 biology
- Regulation of neutrophil reverse migration
- Drug discovery
- Identification of regulators of inflammation via genetic screening
We also have a successful group working on in vivo host-pathogen interaction.
We use a number of models, but our go-to system for seeing innate immunity in action is the Zebrafish.